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18. Unexpected Formation of 4-Aminoquinolones from 4-Hydroxyquinolones with Benzylammoniumchlorid - A New Synthesis of 3-substituted 4-Aminoquinolones
Stadlbauer W., Kappe Th., Synthesis 1981, 833-834

Abstract: The synthesis of 4-amino-2-quinolones 2 by thermal reaction of 4-hydroxy-2-quinolones 1 with benzylammonium chloride is described. The mixture is heated without solvent and the primary product, the 4-benzylamino-2-quinolone 3 is debenzylated at the reaction conditions. In some cases a mixture of 2 and 3 is formed depending on the substituent in position 3.

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