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60. A simple and effective method for the reduction of acyl substituted heterocyclic 1,3-dicarbonyl compounds to alkyl derivatives by zinc - acetic acid- hydrochloric acid
Kappe T., Aigner R., Roschger P., Schnell B., Stadlbauer W., Tetrahedron, 51 (1995), 12923-12928

Abstract: 3-Acyl-4-hydroxy-2(1H)-quinolones were reduced in good yields (66-97%) to 3-alkyl-4-hydroxy-2(1H)-quinolinones using zinc powder (particle size (45 µm) in acetic acid/hydrochloric acid. This method could be transformed to 3-acetyl-4-hydroxy-coumarin, 3-acetyl-4-hydroxy-2-pyranone and 3-acetyl- 4-hydroxy-2(1H)-pyridinone, which yielded the 3-ethyl derivatives.


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