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83. Study of the Thermal Behavior of Azidohetarenes with Differential Scanning Calorimetry(Organic Azides in Heterocyclic Synthesis, Part 30)
Stadlbauer W., Hojas G., J. Biochem. Biophys. Methods, 53, 83-99 (2002)

Abstract: Azidohetarenes have found large interest because of its synthetic value . Their thermal properties were studied by means of differential scanning calorimetry (DSC).
In this work three types of azidohetarenes were studied: Azidohetarenes without reactive ortho substituents which are known to give amines and azo compounds were compared with ortho-phenyl and ortho-acyl substituted azidohetarenes, which gave ring closure reactions either to indoles or to five-membered heterocycles such as isoxazoles. The temperature areas and reaction enthalpies give both information to plan the reaction conditions and important safety information. A further aspect was to find out whether the temperatures or enthalpies give a connection with the three different reaction mechanism which were found for the three different pathways.


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