A novel synthetic strategy for the synthesis of 4-aryl-2(1H)-quinolone compounds for the treatment of male erectile dysfunction is described. Our approach includes a cyclization step, chlorination/hydrolysis, Suzuki C-C coupling,
bromination, and finally a Heck reaction, all under microwave conditions. Having optimized the sequence on mg scale a succesfull MW-scale-up to gram quantities with comparable yields was performed.
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