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109. Regioselective and Sequential Mono- and Diamination of 5,7-Dichloro-pyrido[2,3-d]pyrimidine-2,4-diones
Dang V. T. and W. Stadlbauer, in Proceedings of ECSOC-11, The Eleventh International Electronic Conference on Synthetic Organic Chemistry, http://www.usc.es/congresos/ecsoc/11/ECSOC11.htm, November 1-30, 2007 (a033); J. A. Seijas, Shu-Kun Lin, M. P. Vázquez Tato (Eds). CD-ROM, edition ISBN 3-3-906980-19-7, Published in 2007 by MDPI, Basel, Switzerland.

Abstract:
5-Amino- and 5,7-diamino-pyrido[2,3-d]pyrimidine-2,4-diones were prepared easily from the corresponding 5,7-dichloro-pyrido[2,3-d]pyrimidine-2,4-diones with aliphatic and aromatic amines. The 7-monoazides, obtained by azidation of the chlorides, were converted to iminophosphoranes by reaction with triphenylphosphane via a Staudinger reaction. Hydrolysis produced in one step 7-amino-pyrido[2,3-d]pyrimidine-2,4-diones.


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